Major Depression You may hear your doctor call this "major depressive disorder." You might have this type if you feel depressed most of the time for most days of the week. Some other symptoms you might have are: Loss of interest or pleasure in your activities Weight loss or gain Trouble getting to sleep or feeling sleepy during the day Feelings restless and agitated, or else very sluggish and slowed down physically or mentally Being tired and without energy Feeling worthless or guilty Trouble concentrating or making decisions Thoughts of suicide Your doctor might diagnose you with major depression if you have five or more of these symptoms on most days for 2 weeks or longer. At least one of the symptoms must be a depressed mood or loss of interest in activities. Talk therapy can help. You'll meet with a mental health specialist who will help you find ways to manage your depression . Medications called antid...