Persistent Depressive Disorder If you have depression that lasts for 2 years or longer, it's called persistent depressive disorder. This term is used to describe two conditions previously known as dysthymia (low-grade persistent depression) and chronic major depression. You may have symptoms such as: Change in your appetite (not eating enough or overeating) Sleep too much or too little Lack of energy, or fatigue Low self-esteem Trouble concentrating or making decisions Feel hopeless You may be treated with psychotherapy , medication, or a combination of the two. Bipolar Disorder Someone with bipolar disorder , which is also sometimes called " manic depression ," has mood episodes that range from extremes of high energy with an "up" mood to low "depressive" periods. When you're in the low phase, you'll have the symptoms of major depression. Medication can help bring your mood swings under control. Whether you
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